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|Title:||Design and synthesis of chiral peptidic nucleic acids||Authors:||P., Ciapetti
J. L., Canet
|Issue Date:||1997||Project:||None||Journal:||LETTERS IN PEPTIDE SCIENCE||Abstract:||
Due to the increasing interest in the use of oligonucleotide analogues as antisense and antigene drugs, we designed a chiral analogue constituted of a peptidic frame bearing nucleobases in suitable positions (C-PNA). We recently reported the synthesis of four nonnatural alpha-amino acids with the DNA bases in the lateral chain. In this paper we present an improved synthesis of the Fmoc monomers and their polymerisation to polypeptidic oligonucleotide analogues using a modification of the standard protocol for solid phase peptide synthesis.
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