Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4218
Title: Design and synthesis of chiral peptidic nucleic acids
Authors: P., Ciapetti
A., Mann
A., Schoenfelder
Taddei, Maurizio 
E., Trifilieff
I., Canet
J. L., Canet
Issue Date: 1997
Project: None 
Journal: LETTERS IN PEPTIDE SCIENCE
Abstract: 
Due to the increasing interest in the use of oligonucleotide analogues as antisense and antigene drugs, we designed a chiral analogue constituted of a peptidic frame bearing nucleobases in suitable positions (C-PNA). We recently reported the synthesis of four nonnatural alpha-amino acids with the DNA bases in the lateral chain. In this paper we present an improved synthesis of the Fmoc monomers and their polymerisation to polypeptidic oligonucleotide analogues using a modification of the standard protocol for solid phase peptide synthesis.
Description: 
45969
URI: http://hdl.handle.net/20.500.12779/4218
ISSN: 0929-5666
DOI: 10.1007/BF02442898
Appears in Collections:Publications

Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.