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|Title:||Photoimmobilization of sulphated hyaluronic acid for antithrombogenicity||Authors:||G., Chen
|Issue Date:||1997||Project:||None||Journal:||BIOCONJUGATE CHEMISTRY||Abstract:||
Anticoagulant polymer sulfated hyaluronic acid was patterned immobilized on a poly(ethyleneterephthalate) (PET) film in a specific pattern by photolithography. Hyaluronic acid was sulfated bya sulfur trioxide-pyridine complex. The polymer was coupled with azidoaniline. The derivatizedpolymer was cast on a PET film from aqueous solution. After drying, the film was photoirradiated inthe presence or absence of a photomask. The micropatterning was confirmed by staining with a dye,brilliant green. Since the anticoagulant polymer has negative charges, the cationic dye was adsorbedon the regions where the anticoagulant polymer was immobilized. Platelet adhesion was reduced onthe sulfated hyaluronic acid-immobilized areas. The immobilized sulfated hyaluronic acid significantlyreduced thrombus formation.
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