Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4171
Title: CrCl2 mediated addition of allylic halides or phosphates to N-protected alpha-amino aldehydes. Stereocontrolled synthesis of a new core for C-2 symmetric HIV-protease inhibitors.
Authors: P., Ciapetti
M., Falorni
Taddei, Maurizio 
Issue Date: 1996
Project: None 
Journal: TETRAHEDRON
Abstract: 
The addition of gamma-monosubstituted allylchromium(lll) reagents to N-protected alpha-amino aldehydes proceeds in a stereoconvergent manner in contrast with the case of the unsubstituted reagents, where the stereoselectivity depends on the nature of the group bonded to the nitrogen. The chromium(III) reagent derived from 3-chloromethyl-2-trimethylsilyl-1-propene was used to prepare a C-2 symmetric HIV-protease inhibitor. Copyright (C) 1996 Elsevier Science Ltd
Description: 
45960
URI: http://hdl.handle.net/20.500.12779/4171
ISSN: 0040-4020
DOI: 10.1016/0040-4020(96)00258-X
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