Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4165
Title: DNA-ligand interaction detected by proton-selective and non-selective spin-lattice relaxation rate analysis
Authors: Bonechi, Claudia 
Donati, Alessandro 
Picchi, MARIA PIA
Rossi, Claudio 
Tiezzi, Enzo
Keywords: DNA ligand interaction; proton selective and non-selective spin lattice relaxation rate analysis
Issue Date: 1996
Project: None 
Journal: COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Abstract: 
In this paper, a method based on NMR measurements for studying the ability of ligands to interact withmacromolecule surfaces is proposed. It is based on temperature-dependent NMR proton selective and non-selectivespin lattice relaxation rate experiments and assumes fast chemical exchange conditions of the ligand between free andbound states. The results obtained appear able to identify DNA-psoralen complex formation. The use of thismelhodology for monitoring non-covalent interaction of ligands and bipolymers is suggested.
Description: 
35662
URI: http://hdl.handle.net/20.500.12779/4165
ISSN: 0927-7757
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