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|Title:||DNA-ligand interaction detected by proton-selective and non-selective spin-lattice relaxation rate analysis||Authors:||Bonechi, Claudia
Picchi, MARIA PIA
|Keywords:||DNA ligand interaction; proton selective and non-selective spin lattice relaxation rate analysis||Issue Date:||1996||Project:||None||Journal:||COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS||Abstract:||
In this paper, a method based on NMR measurements for studying the ability of ligands to interact withmacromolecule surfaces is proposed. It is based on temperature-dependent NMR proton selective and non-selectivespin lattice relaxation rate experiments and assumes fast chemical exchange conditions of the ligand between free andbound states. The results obtained appear able to identify DNA-psoralen complex formation. The use of thismelhodology for monitoring non-covalent interaction of ligands and bipolymers is suggested.
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