Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4103
Title: Cholinesterase inhibitors increase secretion of APPs in rat brain cortex
Authors: Mori, F.
Lai, C.
Fusi, Fabio 
Giacobini, E.
Issue Date: 1995
Project: None 
Journal: NEUROREPORT
Abstract: 
We examined whether cholinesterase inhibitors (ChEI) could alter the release of amyloid precursor protein (APP) from superfused brain cortical slices of the rat. Three ChEI, both reversible and irreversible, were tested for their ability to enhance the release of nonamyloidogenic soluble derivatives (APPs). These included: physostigmine (PHY), heptyl-physostigmine (HEP) and 2,2-dichloro-vinyldimethyl phosphate (DDVP), at concentrations producing cholinesterase (ChE) inhibition ranging from 5% to 95%. All three ChEI elevated APPs release significantly above control levels. Electrical field stimulation significantly increased the release of APPs within 50 min. Similar increase was observed after muscarinic receptor stimulation with bethanechol (BETHA). Tetrodotoxin (TTX) completely blocked the effect of electrical stimulation. These findings suggest that administration of ChEI to Alzheimer's disease (AD) patients may have a neuroprotective effect by activating normal APP processing.
Description: 
57060
URI: http://hdl.handle.net/20.500.12779/4103
ISSN: 0959-4965
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