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|Title:||SYNTHESIS AND MOLECULAR MODELING OF TAXANES MODIFIED AT RING-C||Authors:||Menichincheri, M
|Issue Date:||1995||Project:||None||Journal:||MEDICINAL CHEMISTRY RESEARCH||Abstract:||
Some new paclitaxel analogs, modified at ring C, - namely the 7-alpha-mesylate, 7-deoxy-7-alpha-amino, 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-5 alpha-acetoxy-Delta(6,7)-20-O-seco and 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-6,7-epoxy-20-O-seco derivatives -are presented. The biological activity of 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-5 alpha-acetoxy-Delta(6,7)-20-O-seco, 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-5 alpha-acetoxy-6,7-epoxy-20-O-seco, 7-deoxy-7-alpha-azido, 7-deoxy-7-alpha-amino and 6,7-epoxy derivatives have been evaluated A molecular modeling study on some paclitaxel derivatives has been done in an attempt to rationalize the difference in biological activity.
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