Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4094
Title: SYNTHESIS AND MOLECULAR MODELING OF TAXANES MODIFIED AT RING-C
Authors: Menichincheri, M
Botta, Maurizio 
Ceccarelli, W
Ciomei, M
Corelli, Federico 
Danello, M
Fusarbassini, D
Mongelli, N
Pesenti, E
Pinciroli, V
Tafi, Andrea 
Vanotti, E.
Issue Date: 1995
Project: None 
Journal: MEDICINAL CHEMISTRY RESEARCH
Abstract: 
Some new paclitaxel analogs, modified at ring C, - namely the 7-alpha-mesylate, 7-deoxy-7-alpha-amino, 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-5 alpha-acetoxy-Delta(6,7)-20-O-seco and 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-6,7-epoxy-20-O-seco derivatives -are presented. The biological activity of 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-5 alpha-acetoxy-Delta(6,7)-20-O-seco, 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-5 alpha-acetoxy-6,7-epoxy-20-O-seco, 7-deoxy-7-alpha-azido, 7-deoxy-7-alpha-amino and 6,7-epoxy derivatives have been evaluated A molecular modeling study on some paclitaxel derivatives has been done in an attempt to rationalize the difference in biological activity.
Description: 
49342
URI: http://hdl.handle.net/20.500.12779/4094
ISSN: 1054-2523
Appears in Collections:Publications

Show full item record

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.