Please use this identifier to cite or link to this item:
|Title:||New Heterocyclic Analogs of Suramin with bFGF Inhibiting Activity. Synthesis, SAR and Possible Mode of Action||Authors:||G., Biasoli
|Issue Date:||1994||Project:||None||Journal:||MEDICINAL CHEMISTRY RESEARCH||Abstract:||
Some heterocyclic analogs of suramin with potent and selective basic fibroblast growth factor (bFGF) complexing activity have been synthesized. The possible mode of action of these compounds, deduced on the basis of SAR, biological properties and molecular modeling studies, entails a unique bidentate binding of the ligands to both the heparin and receptor binding sites of the growth factor
|Appears in Collections:||Publications|
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.