Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4024
Title: Non-steroidal antiinflammatory agents. Synthesis and enzyme inhibition of 2-[4-(heteroarylmethyl)phenil] propanoic acids and analogues
Authors: Silvestri, R.
Pagnozzi, E.
Valoti, Massimo
Fusi, Fabio 
Issue Date: 1994
Project: None 
Journal: IL FARMACO
Abstract: 
Some 2-[4-(heteroarylmethyl)phenyl]propanoic acids and phenylacetic and benzoic analogues has been synthesized. All above acids were tested for their inhibitory activity on lipoxygenase and cyclooxygenase, in comparison with NDGA and tolmetin. 2-[4-(Thien-2-ylmethyl)phenyl]propanoic acid 2, strictly related with suprofen, was found the most interesting compound, giving rise to a 79% inhibition of the cyclooxygenase activity at 10(-4) M concentration.
Description: 
57061
URI: http://hdl.handle.net/20.500.12779/4024
ISSN: 0014-827X
Appears in Collections:Publications

Show full item record

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.