Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4019
DC FieldValueLanguage
dc.contributor.authorPacini, A.en_us
dc.contributor.authorTorricelli, Claudiaen_us
dc.contributor.authorSantucci, Annalisaen_us
dc.contributor.authorMaioli, Emanuelaen_us
dc.date.accessioned2021-03-30T14:41:10Z-
dc.date.available2021-03-30T14:41:10Z-
dc.date.issued1994-
dc.identifier.issn0749-5331en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/4019-
dc.description36411en_US
dc.description.abstractIdentification of atrial natriuretic factor (ANF) in the mammalian heart demonstrates that the heart is an endocrine organ. Radioimmunoassay combined with chromatographic separation has revealed different molecular forms of ANF circulating in plasma, including a macromolecular form referred to as ''big ANF'' The present study was undertaken to purify and characterize this circulating form in human blood. The chromatographic behaviour of the ANF in the fractionation of human plasma on Affi-Gel Blue under different conditions of ionic strength has been described. All the fractions collected were analyzed by SDS-PAGE. Measurement of ANF was carried out by RIA. Immunoblot analysis with eluant buffers of the highest and lowest ionic strengths showed the presence respectively of an immunoreactive band with a molecular weight of approximately 89 kd and of an immunoreactive region in the range of molecular weight higher than 116 kd. These data suggest that at least two plasma proteins may function as carriers of ANF.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofBIOCHEMICAL ARCHIVESen_US
dc.titleMacromolecular forms of atrial natriuretic factor in human plasma.en_US
dc.typeArticleen_US
dc.identifier.scopus2-s2.0-0028083748en_US
dc.identifier.isiWOS:A1994MV85300001en_US
dc.relation.volume10en_US
dc.description.firstpage1en_US
dc.description.lastpage10en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0001-6976-9086-
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