Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4015
Title: Crcl2 Mediated Allylation of N-protected Alpha-amino Aldehydes - A Versatile Synthesis of Polypeptides Containing An Hydroxyethylene Isostere
Authors: P., Ciapetti
Taddei, Maurizio 
P., Ulivi
Issue Date: 1994
Project: None 
Journal: TETRAHEDRON LETTERS
Abstract: 
Differently substituted allylic bromides react with N-protected amino aldehydes to give intermediate products for the synthesis of hydroxyethylene dipeptide isosteres. The low stereoselectivity of this reaction can be improved using aldehydes protected with hindered groups. This reaction can be efficiently applied to oligopetide aldehydes. We describe a protocol, for the preparation of peptides containing an hydroxyethylene isostere, which allows a rapid variations of the aminoacid sequence
Description: 
45951
URI: http://hdl.handle.net/20.500.12779/4015
ISSN: 0040-4039
DOI: 10.1016/S0040-4039(00)76862-6
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