Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3974
Title: Pyrazolo[4,3-c]quinolines. Synthesis and specific inhibition of benzodiazepine receptor binding. Note II
Authors: Savini, Luisa
Massarelli, Paola
Corti, Piero
Pellerano, Cesare
Bruni, Giancarlo
Romeo, M. R.
Issue Date: 1993
Project: None 
Journal: IL FARMACO
Abstract: 
Two new series od 2-arylpyrazolo[4,3-c]quinolin-3-ones (6,8-difluoro- and 7,9-dichloro-derivatives) have been synthesized and tested for their ability to displace [H-3]flunitrazepam from rat brain membranes. Several compounds possess comparable and sometimes higher affinity for central benzodiazepine receptors than that of diazepam. Some selected compounds were also tested in vivo in the anti-pentylenetetrazol test; some anticovulsant activity resulted for the 6,8-difluoroderivatives only.
Description: 
4642
URI: http://hdl.handle.net/20.500.12779/3974
ISSN: 0014-827X
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