Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3968
Title: 2-(chloromethyl)-2-(trimethylsilyl)-1-propene - A Convenient Reagent For the Synthesis of Methylenetetrahydrofurans and Methylenebutyrolactones
Authors: F., Daniello
D., Mattii
Taddei, Maurizio 
Issue Date: 1993
Project: None 
Journal: SYNLETT
Abstract: 
The title reagent was used in reaction with aldehydes in the presence of BF3. OEt2 to give hydroxy allylic chlorides which were further transformed into tetrahydrofurans using DBU and LiClO4. Alternatively butyrolactones could be prepared from the same intermediates after oxidation of the chloro allylic functionality. Starting from isoleucine we prepared a methylenebutyrolactone which has been used in the synthesis of several enzyme inhibitors.
Description: 
45944
URI: http://hdl.handle.net/20.500.12779/3968
ISSN: 0936-5214
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