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|Title:||2-(chloromethyl)-2-(trimethylsilyl)-1-propene - A Convenient Reagent For the Synthesis of Methylenetetrahydrofurans and Methylenebutyrolactones||Authors:||F., Daniello
The title reagent was used in reaction with aldehydes in the presence of BF3. OEt2 to give hydroxy allylic chlorides which were further transformed into tetrahydrofurans using DBU and LiClO4. Alternatively butyrolactones could be prepared from the same intermediates after oxidation of the chloro allylic functionality. Starting from isoleucine we prepared a methylenebutyrolactone which has been used in the synthesis of several enzyme inhibitors.
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checked on May 12, 2021
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