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|Title:||Substantivity of sunscreens. In vitro evaluation of the transdermal permeation characteristics of some benzophenone derivatives.||Authors:||Monti, D.
|Keywords:||Skin permeatio; quaternary ammonium; Benzophenone derivatives||Issue Date:||1993||Project:||None||Journal:||INTERNATIONAL JOURNAL OF COSMETIC SCIENCE||Abstract:||
The in vitro permeation through excised hairless mouse skin of a series of 4-O-(N, N-dimethylaminoalkyl)-benzophenones, non-quaternarized and quaternarized, and of two commercial benzophenone sunscreens, taken as reference compounds, was investigated. The aim of the study was to verify the skin penetration of the highly skin-substantive quaternary ammonium derivatives, in comparison with their parent, non-quaternarized compounds. While the quaternary derivatives proved unable to permeate the skin during the period of observation (45 h), their parent amine hydrochlorides and the reference sunscreens (2-hydroxy-4-methoxy-benzophenone-5-sulphonic acid and 2,2′-dihydroxy-4,4′-dimethoxy-benzophenone 5,5′-sodium disulphonate), showed appreciable transdermal fluxes.These data indicate that the presence of a quaternary ammonium group in a molecule, besides inducing a high affinity for cutaneous keratin, may result in hindered or reduced transdermal (and possibly systemic) absorption. Both features may contribute in improving the safety of a cosmetic sunscreen.
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