Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3966
Title: Substantivity of sunscreens. In vitro evaluation of the transdermal permeation characteristics of some benzophenone derivatives.
Authors: Monti, D.
Saettone, M.
Centini, Marisanna 
Anselmi, Cecilia
Keywords: Skin permeatio; quaternary ammonium; Benzophenone derivatives
Issue Date: 1993
Project: None 
Journal: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
Abstract: 
The in vitro permeation through excised hairless mouse skin of a series of 4-O-(N, N-dimethylaminoalkyl)-benzophenones, non-quaternarized and quaternarized, and of two commercial benzophenone sunscreens, taken as reference compounds, was investigated. The aim of the study was to verify the skin penetration of the highly skin-substantive quaternary ammonium derivatives, in comparison with their parent, non-quaternarized compounds. While the quaternary derivatives proved unable to permeate the skin during the period of observation (45 h), their parent amine hydrochlorides and the reference sunscreens (2-hydroxy-4-methoxy-benzophenone-5-sulphonic acid and 2,2′-dihydroxy-4,4′-dimethoxy-benzophenone 5,5′-sodium disulphonate), showed appreciable transdermal fluxes.These data indicate that the presence of a quaternary ammonium group in a molecule, besides inducing a high affinity for cutaneous keratin, may result in hindered or reduced transdermal (and possibly systemic) absorption. Both features may contribute in improving the safety of a cosmetic sunscreen.
Description: 
35527
URI: http://hdl.handle.net/20.500.12779/3966
ISSN: 0142-5463
DOI: 10.1111/j.1467-2494 1993.tb00068.x
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