Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3965
DC FieldValueLanguage
dc.contributor.authorRustici, M.en_us
dc.contributor.authorBracci, Luisaen_us
dc.contributor.authorLozzi, Luisaen_us
dc.contributor.authorNeri, Paoloen_us
dc.contributor.authorSantucci, Annalisaen_us
dc.contributor.authorSoldani, Patriziaen_us
dc.contributor.authorSpreafico, Adrianoen_us
dc.contributor.authorNiccolai, Nerien_us
dc.date.accessioned2021-03-30T14:36:34Z-
dc.date.available2021-03-30T14:36:34Z-
dc.date.issued1993-
dc.identifier.issn0006-3525en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/3965-
dc.description36432en_US
dc.description.abstractThe glycoprotein from the neurotropic rabies virus shows a significant homology with the alpha neurotoxin that binds to the nicotinic acetylcholine receptor. The crystal structure of the alpha neurotoxins suggests that the Arg 37 guanidinium group and the Asp 31 side-chain carboxylate of the erabutoxin have stereochemical features resembling those of acetylcholine. Conformational studies on the Asn194-Ser195-Arg196-Gly197 tetrapeptide, an essential part of the binding site of the rabies virus glycoprotein, indicate that the side chains of Asn and Arg could also mimic the acetylcholine structure. This observation is consistent with the recently proposed mechanism of the viral infection.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofBIOPOLYMERSen_US
dc.titleA model of the rabies virus glycoprotein active siteen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/bip.360330612en_US
dc.identifier.pmid8318668en_US
dc.identifier.scopus2-s2.0-0027610277en_US
dc.identifier.isiWOS:A1993LC52800011en_US
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/bip.360330612/abstracten_US
dc.relation.volume33(6)en_US
dc.description.firstpage961en_US
dc.description.lastpage969en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0001-6976-9086-
crisitem.author.orcid0000-0002-4320-9950-
crisitem.author.orcid0000-0002-6919-6908-
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