Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3959
Title: A palladium-catalyzed route to huperzine A and its analogs and their anticholinesterase activity
Authors: Campiani, Giuseppe 
Li Qiang, Sun
Alan P., Kozikowski
Patricia, Aagaard
Michael, Mckinney
Issue Date: 1993
Project: None 
Journal: JOURNAL OF ORGANIC CHEMISTRY
Abstract: 
Huperzine A is an alkaloid isolated from Huperzia serrata (Thunb.) Trev., a Chinese club moss the extracts of which have been used in Chinese folklore medicine to treat a variety of maladies including memory disorders. Recently, this molecule has attracted widespread attention because of its possible use in the treatment of Alzheimer's disease (AD). We describe herein a palladium-catalyzed bicycloannulation route to this molecule which makes huperzine A available in 40% overall yield. The application of this methodology to seven other huperzine A analogues together with their biological activity in the inhibition of rat cortex acetylcholinesterase (AChE) is detailed herein. None of these new compounds was more potent than the parent structure as AChE inhibitors.
Description: 
44464
URI: http://hdl.handle.net/20.500.12779/3959
ISSN: 0022-3263
DOI: 10.1021/jo00079a008
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