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|Title:||A Modification of the Hiyama Reaction - Synthesis of Homo Allylic Amines From Imines and Allylic Bromides In the Presence of Crcl2||Authors:||M., Giammaruco
|Issue Date:||1993||Project:||None||Journal:||TETRAHEDRON LETTERS||Abstract:||
Arylic and alkylic imines, activated with BF3.OEt2 react with different allylic bromides in the presence of CrCl2 to give the corresponding homo allylic amines. The reaction can be performed in a single step starting from the aldehyde and the amine, in the presence of molecular sieves (4 angstrom), in a sort of amino-allylation of aldehydes. With the imine derived from benzaldehyde and (S)-valine a good diastereomeric excess (86%) is obtained.
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