Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3912
Title: Proton and Carbon Chemical Shift Assignment and Dynamic Investigation of the Macrolide Antibiotic Tylosin
Authors: Rossi, Claudio 
Donati, Alessandro 
Picchi, M. P.
Sansoni, M. R.
Corbini, Gianfranco 
Corti, Piero
Issue Date: 1992
Project: None 
Journal: MAGNETIC RESONANCE IN CHEMISTRY
Abstract: 
The NMR spectral properties of the antibiotic tylosin were investigated. DQ-COSY and HETCOR two-dimensional spectra were used for the assignment of both the proton and protonated carbon signals. Selective (H)C-NOE, were proposed for the controversial quaternary carbon assignments. The analysis of molecular motion in solution based on carbon spin–lattice relaxation rates shows that tylosin exhibits dynamics that are typical of each molecular moiety. A higher degree of free motion is observed with increasing distance from the macrolide nucleus.
Description: 
37505
URI: http://hdl.handle.net/20.500.12779/3912
ISSN: 0749-1581
DOI: 10.1002/mrc.1260301007
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