Please use this identifier to cite or link to this item:
|Title:||Proton and Carbon Chemical Shift Assignment and Dynamic Investigation of the Macrolide Antibiotic Tylosin||Authors:||Rossi, Claudio
Picchi, M. P.
Sansoni, M. R.
|Issue Date:||1992||Project:||None||Journal:||MAGNETIC RESONANCE IN CHEMISTRY||Abstract:||
The NMR spectral properties of the antibiotic tylosin were investigated. DQ-COSY and HETCOR two-dimensional spectra were used for the assignment of both the proton and protonated carbon signals. Selective (H)C-NOE, were proposed for the controversial quaternary carbon assignments. The analysis of molecular motion in solution based on carbon spin–lattice relaxation rates shows that tylosin exhibits dynamics that are typical of each molecular moiety. A higher degree of free motion is observed with increasing distance from the macrolide nucleus.
|Appears in Collections:||Publications|
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.