Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3898
Title: A Convenient Approach To Hydroxyethylene Dipeptide Isosteres Using Allylsilane Chemistry
Authors: F., Daniello
S., Gehanne
Taddei, Maurizio 
Issue Date: 1992
Project: None 
Journal: TETRAHEDRON LETTERS
Abstract: 
2-Chloromethyl-3-trimethylsilyl-1-propene reacts with N-Boc amino aldehydes in the presence of BF3 OEt2 to give selectively the corresponding (S)-homoallylic alcohols. These compounds can be easily transformed into hydroxyethylene dipeptide isosteres through elaboration of the allylic chloride part of the molecule. The preparation of Ilepsi[CH(OH)CH2]Glu and of Ilepsi[CH(OH)CH2]Ala (in a protected form) is described.
Description: 
45943
URI: http://hdl.handle.net/20.500.12779/3898
ISSN: 0040-4039
DOI: 10.1016/S0040-4039(00)61163-2
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