Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3861
DC FieldValueLanguage
dc.contributor.authorS. G., Haroutiunianen_us
dc.contributor.authorB., Brunien_us
dc.contributor.authorR., Monnannien_us
dc.contributor.authorP., Oriolien_us
dc.contributor.authorMangani, Stefanoen_us
dc.date.accessioned2021-03-30T14:36:07Z-
dc.date.available2021-03-30T14:36:07Z-
dc.date.issued1991-
dc.identifier.issn0020-1693en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/3861-
dc.description47999en_US
dc.description.abstractThe binding of cis-diamminedichloroplatinum(II) (cis-DDP) to DNA is investigated as a function of the GC content and of the cis-DDP concentration. Analysis of the melting curves and of the UV and CD spectra shows that binding of cis-DDP to DNA is highly sequence specific, GC rich DNAs being destabilized more effectively. At low levels of platination, stabilization of GC- and destabilization of AT-base pairs can be noted. In AT rich DNA, cis-DDP binding favours the B --> A conformational transition. It is also shown that, in addition to specific interactions between cis-DDP and DNA, several non-specific processes take place.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofINORGANICA CHIMICA ACTAen_US
dc.subjectDNA; calorimetryen_US
dc.titleThe Dependence of Cis-diamminedichloroplatinum(ii) Binding To Dna Upon the Gc Content - A Thermal and Spectrophotometric Investigationen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0020-1693(00)83054-6en_US
dc.identifier.scopus2-s2.0-0001489807en_US
dc.identifier.isiWOS:A1991FZ90800018en_US
dc.relation.volume184en_US
dc.relation.issue1en_US
dc.description.firstpage127en_US
dc.description.lastpage132en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0003-4824-7478-
Appears in Collections:Publications
Show simple item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.