Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3860
Title: The interaction of antioxidants and structurally related compounds with mitochondrial oxidative phosphorylation.
Authors: Fusi, Fabio 
Valoti, Massimo
Sgaragli, GIAN PIETRO
Murphy, Mp
Issue Date: 1991
Project: None 
Journal: METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
Abstract: 
The antioxidants, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), interact with mitochondrial oxidative phosphorylation in two ways. They uncouple phosphorylation from oxidation by making the mitochondrial inner membrane more permeable to protons. They also inhibit respiration by a direct interaction with the electron transport chain. Here we separated out these two properties of BHA and BHT by determining their effects on respiration in coupled and uncoupled mitochondria. Similar experiments were carried out with compounds structurally related to BHA and BHT. Most of these compounds had uncoupling and inhibitory properties essentially similar to BHA and BHT. In contrast, the dimer of BHA had no inhibitory effects on uncoupled respiration and little uncoupling activity. The implications of these results for the interactions of BHA and BHT with mitochondrial oxidative phosphorylation and the design of antioxidants are discussed.
Description: 
50407
URI: http://hdl.handle.net/20.500.12779/3860
ISSN: 0379-0355
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