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|Title:||Thermodynamic and FT-IR spectroscopic studies on heparin-polycation interaction||Authors:||R., Barbucci
|Issue Date:||1991||Project:||None||Journal:||CLINICAL MATERIALS||Abstract:||
PUPA surfaces are capable of adsorbing heparin because the basic nitrogens of poly(amido-amine), once protonated, electrostatically interact with the negative charges carried by the heparin molecule. At first, the protonation behaviour of PUPA surfaces was investigated by thermodynamic and spectroscopic techniques. Then, the heparin polycation interaction was studied. Both sulphate and carboxyl groups of heparin are involved in the ionic binding if the heparinization is carried out at pH = 5·5, whereas only the former electrostatically interact at pH = 3·0. A certain amount of heparin remained bound to the PUPA surfaces even at pH ∼ 11, emphasizing that strong bases are not able to destroy the ionic bond.
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