Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3857
Title: Conformational features of imipramine hydrochloride in aqueous solution as detected by 1H NMR relaxation analysis
Authors: Gaggelli, Elena 
Marchettini, Nadia
Valensin, Gianni 
Issue Date: 1991
Project: None 
Journal: MAGNETIC RESONANCE IN CHEMISTRY
Abstract: 
Proton NMR measurements were performed and H-1-H-1 dipolar interaction energies were measured to delineate the conformation of imipramine in solution. Self-association of imipramine into dimers was observed and a dimerization constant of 12 l mol-1 was calculated. The motional correlation times for the monomer and the dimer were calculated at tau-cm = 0.18 ns and tau-cd = 0.36 ns, respectively. The geometry of the self-stacked dimer was analysed by measuring intermolecular dipolar cross-relaxation rates and interpreted in terms of the conformation of the aminoalkyl moiety.
Description: 
49483
URI: http://hdl.handle.net/20.500.12779/3857
ISSN: 0749-1581
DOI: 10.1002/mrc.1260290912
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