Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3825
Title: NMR investigation of cell cultures: early detection of infection by Herpes simplex virus type 2 and transformation
Authors: Valensin, PIER EGISTO
BIANCHI BANDINELLI, MARIA LETIZIA
Zazzi, Maurizio
Gaggelli, Elena 
Valensin, Gianni 
Issue Date: 1990
Project: None 
Journal: MICROBIOLOGICA
Abstract: 
The water proton Nuclear Magnetic Resonance (NMR) spin-lattice relaxation rates were measured in suspension of uninfected and Herpes simplex virus type 2-infected WI-38 diploid cells and shown to allow reliable detection of (i) the early signs of productive infection, and (ii) the tendency to undergo either spontaneous or virus-induced transformation. In addition, NMR investigation of several transformed cell lines currently and previously established from WI-38 cells clearly indicated that the NMR relaxation parameter is a suitable tool for assessment of the level of malignancy, as revealed by in vivo oncogenicity tests in immunosuppressed mice.
Description: 
24944
URI: http://hdl.handle.net/20.500.12779/3825
ISSN: 0391-5352
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