Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3822
Title: 1H-NMR studies on the self-association of chloroquine in aqueous solution
Authors: Marchettini, Nadia
Valensin, Gianni 
Gaggelli, Elena 
Issue Date: 1990
Project: None 
Journal: BIOPHYSICAL CHEMISTRY
Abstract: 
The concentration dependences of 1H-NMR chemical shifts and spin-lattice relaxation rates were measured for chloroquine in aqueous solution. The weak self-association constant was evaluated according to a dimerization equilibrium with the formation of self-stacked adducts (Kd = 4.52 +/- 0.68 l mol-1). The motional correlation times were evaluated for the monomer and the dimer by measuring intramolecular dipolar cross-relaxation rates of aromatic vicinal protons (tau cm = 0.06 ns and tau cd = 0.26 ns). The geometry of the stacked dimer was elucidated by measuring intermolecular dipolar cross-relaxation rates and interpreted in terms of partial superposition of quinoline moieties.
Description: 
49943
URI: http://hdl.handle.net/20.500.12779/3822
ISSN: 0301-4622
DOI: 10.1016/0301-4622(90)85008-T
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