Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3773
Title: 1H and 13C NMR Conformational Analysis of Adrenergic Drugs. Part 2. N-Isopropyl-N-{3-[4(4-Methoxybenzoylamino)Phenoxy]-2-Hydroxypropyl} Ammonium Chloride, a New β1-Blocking Agent
Authors: Gaggelli, Elena 
Marchettini, Nadia
Sega, Alessandro 
Valensin, Gianni 
Issue Date: 1989
Project: None 
Journal: SPECTROSCOPY LETTERS
Abstract: 
Dynamic and structural features of N-Isopropyl-N- {3-[4(4-Methoxybenzoylamino)Phenoxy]-2-Hydroxypropyl} Ammonium Chloride in [2H6]DMSO were investigated by measuring 13C and 1H spin-lattice relaxation rates and 13C- {1H} and 1H- {1H} n.O.e. Correlation times for main and internal reorientational motions were interpreted in terms of internal rotation around the two planal axes. Selective and double-selective 1H spin-lattice relaxation rates were measured, wherefrom relevant proton-proton intramolecular distances were calculated. It was shown that the β1− blocking agent assumes a preferred conformation where extensive intramolecular H-bonding prevents segmental motion along the quaternary ammonium sidechain.
Description: 
50097
URI: http://hdl.handle.net/20.500.12779/3773
ISSN: 0038-7010
DOI: 10.1080/00387018908053957
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