Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3705
Title: Biomolecular Dynamics and Electron Spin Resonance Spectra of Copper Complexes of Antitumor Agents in solution
Authors: Basosi, Riccardo 
Pogni, Rebecca 
Tiezzi, Enzo
W. E., Antholine
L. C., Moscinsky
Keywords: EPR; copper complexes; antitumor activity of Rifamycin SV; metal ions in solution
Issue Date: 1987
Project: None 
Journal: JOURNAL OF THE CHEMICAL SOCIETY. FARADAY TRANSACTIONS I
Abstract: 
Rifamycin SV has been characterized as a powerful inhibitor of RNA synthesis by certain prokaryotic RNA polymerases. It has been proposed that the antitumor activity of Rifamycin SV is due to its ability to chelate metal ions in solutions, thus decreasing their availability to act as coenzymes for RNA polymerase. In this report, a two-step approach based on free-radical generation and metal complexation in solution was followed by e.s.r. spectroscopy. The e.s.r. measurements and u.v.-visible titration show by pH cycling that complexation is pH-dependent. In addition, the stability of these complexes in minimal essential media (MEM) was investigated
Description: 
40466
URI: http://hdl.handle.net/20.500.12779/3705
ISSN: 0300-9599
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