Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3613
Title: Interaction Between Low-Affinity Cupric Ion and Human Methemoglobin
Authors: ANTHOLINE W., E
Basosi, Riccardo 
HYDE J., S
Taketa, F.
Issue Date: 1984
Project: None 
Journal: JOURNAL OF INORGANIC BIOCHEMISTRY
Abstract: 
Human hemoglobin has been shown to contain a high- as well as a low-affinity binding site for cupric ion on each of its constitutent β chains. The copper that is bound to the low-affinity site has been implicated in the selective oxidation of the β hemes. In the present work a low-affinity binding site for cupric ion has been located within 10 Å of the heme iron in human hemoglobin. It is suggested that the proximal histidine is involved in the binding of copper at this site and that it participates in the oxidation of heme iron and reduction of cupric ion.
Description: 
18875
URI: http://hdl.handle.net/20.500.12779/3613
ISSN: 0162-0134
DOI: 10.1016/0162-0134(84)85045-X
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