Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/3526
Title: Coordination behaviour of antithyroid drugs against the Fe(I)(NO)2 group in solution: ESR and FT-NMR study.
Authors: Basosi, Riccardo 
Niccolai, Neri 
Rossi, Claudio 
Issue Date: 1978
Project: None 
Journal: BIOPHYSICAL CHEMISTRY
Abstract: 
The binding sites of some types of antithyroid drugs in the presence of the Fe(I)(NO)2 paramagnetic probe were investigated. Coordination behaviour in solution of different structured ligands was determined by means of ESR parameters and 13C FT-NMR spectra. Selective isotopic substitution with 15NO combined with computer simultation was used to elucidate overlapping ESR patterns. A correlation between chemical structure and antithyroid activity of the pharmacological bases is suggested.
Description: 
48528
URI: http://hdl.handle.net/20.500.12779/3526
ISSN: 0301-4622
DOI: 10.1016/0301-4622(78)85023-6
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