Browsing by Author Schenone, S.

Showing results 1 to 19 of 19
Issue DateTitleAuthor(s)Third Mission
2013Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders.Botta, Maurizio ; Schenone, S.; Botta, Maurizio Not applicable
2013An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidinesBotta, Maurizio ; Bernardo, Vincenzo; Vignaroli, Giulia; Brai, Annalaura; Biava, M.; Schenone, S.; Botta, Maurizio Not applicable
2004Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line.Schenone, S.; Bruno, O.; Bondavalli, F.; Ranise, A.; Mosti, L.; Menozzi, G.; Fossa, P.; Donnini, Sandra; Santoro, A.; Ziche, Marina; Manetti, Fabrizio ; Botta, Maurizio Not applicable
2014Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studiesSchenone, S.; Radi, M.; Musumeci, F.; Brullo, C.; Botta, Maurizio Not applicable
2006A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitorsManetti, Fabrizio ; Locatelli, G. A.; Maga, G.; Schenone, S.; Modugno, M.; Forli, S.; Corelli, Federico ; Botta, Maurizio Not applicable
2013A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitorsMori, Mattia ; Tintori, Cristina; Christopher, R. S. A.; Radi, M.; Schenone, S.; Musumeci, F.; Brullo, C.; Sanità, P.; Delle Monache, S.; Angelucci, A.; Kissova, M.; Crespan, E.; Maga, G.; Botta, Maurizio Not applicable
2012A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model:from in silico screening to cyclodextrin formulationBotta, Maurizio ; Evensen, L.; Dreassi, Elena ; Zamperini, Claudio; Caporicci, M.; Falchi, Federico; Musumeci, A.; Schenone, S.; Lorens, J. B.; Botta, Maurizio Not applicable
2014Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma.Tintori, Cristina; Fallacara, A. L.; Radi, Marco; Zamperini, Claudio; Dreassi, Elena ; Crespan, E.; Maga, G.; Schenone, S.; Musumeci, F.; Brullo, C.; Richters, A.; Gasparrini, F.; Angelucci, A.; Festuccia, C.; Delle Monache, S.; Rauh, D.; Botta, Maurizio Not applicable
2013Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutantBotta, Maurizio ; Tintori, Cristina; Musumeci, F.; Brullo, C.; Zamperini, Claudio; Dreassi, Elena ; Fallacara, ANNA LUCIA; Vignaroli, Giulia; Crespan, E.; Zanoli, S.; Laurenzana, Ilaria; Filippi, I.; Maga, G.; Schenone, S.; Angelucci, A.; Botta, Maurizio Not applicable
2012Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitorsBotta, Maurizio ; Falchi, F.; Garbelli, A.; Samuele, A.; Bernardo, V.; Paolucci, S.; Baldanti, F.; Schenone, S.; Manetti, Fabrizio ; Maga, G; Botta, Maurizio Not applicable
2014Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl.Vignaroli, Giulia; Mencarelli, M.; Sementa, Deborah; Crespan, E.; Kissova, M.; Maga, G.; Schenone, S.; Botta, Maurizio ; Botta, Maurizio Not applicable
2019Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell linesFallacara, A. L.; Passannanti, Raffaele ; Mori, Mattia ; Iovenitti, Giulia ; Musumeci, F.; Greco, C.; Crespan, E.; Kissova, M.; Maga, G.; Tarantelli, C.; Spriano, F.; Gaudio, E.; Bertoni, F.; Botta, Maurizio ; Schenone, S.Not applicable
2011Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells.Botta, Maurizio ; Brullo, C.; Crespan, E.; Tintori, Cristina; Musumeci, F.; Biava, M.; Schenone, S.; Dreassi, Elena ; Zamperini, Claudio; Maga, G.; Pagano, D.; Angelucci, A.; Bologna, M.; Botta, Maurizio Not applicable
2013Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl InhibitorsVignaroli, Giulia; Zamperini, Claudio; Dreassi, Elena ; Radi, Marco; Angelucci, A.; Sanità, P.; Crespan, E.; Kissova, M.; Maga, G.; Schenone, S.; Musumeci, F.; Botta, Maurizio Not applicable
2004Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells.Carraro, Fabio; Pucci, Annalisa; Naldini, Antonella; Schenone, S.; Bruno, O.; Ranise, A.; Bondavalli, B.; Brullo, C.; Fossa, P.; Menozzi, G.; Mosti, L.; Manetti, Fabrizio ; Botta, Maurizio Not applicable
2005Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines, potent and selective inhibitors of A1 adenosine receptors.Manetti, Fabrizio ; Schenone, S.; Bondavalli, F.; Brullo, C.; Bruno, O.; Ranise, A.; Mosti, L.; Menozzi, G.; Fossa, P.; Trincavelli, M. L.; Martini, C.; Martinelli, A.; Tintori, Cristina; Botta, Maurizio Not applicable
2004Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines 4-Amino Substituted and Their Biological Evaluation.Schenone, S.; Bruno, O.; Bondavalli, F.; Ranise, A.; Mosti, L.; Menozzi, G.; Fossa, P.; Manetti, Fabrizio ; Morbidelli, Lucia; Trincavelli, L.; Martini, C.; Lucacchini, A.Not applicable
2006Synthesis of New Piperazine-pyridazinone Derivatives and their Binding Affinity toward alpha1-, alpha2-Adrenergic and 5-HT-1A Serotoninergic ReceptorsBetti, L.; Zanelli, M.; Giannaccini, G.; Manetti, Fabrizio ; Schenone, S.; Strappaghetti, G.Not applicable
2002Synthesis, molecular modeling studies, and pharmacological activity of selective A1 receptor antagonistsBondavalli, F.; Botta, Maurizio ; Bruno, O.; Ciacci, A.; Corelli, Federico ; Fossa, P.; Lucacchini, A.; Manetti, Fabrizio ; Martini, C.; Menozzi, G.; Mosti, L.; Ranise, A.; Schenone, S.; Tafi, Andrea ; Trincavelli, M. L.Not applicable