Browsing by Author Schenone, S


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Issue DateTitleAuthor(s)Third Mission
20102-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.Dreassi, Elena ; Zizzari, ALESSANDRA TANIA; Mori, Mattia ; Filippi, Irene; Belfiore, Amalia; Naldini, Antonella; Carraro, Fabio; Santucci, Annalisa ; Schenone, S; Botta, Maurizio Not applicable
20093D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors.Falchi, F; Manetti, Fabrizio ; Carraro, Fabio; Naldini, Antonella; Maga, G; Crespan, E; Schenone, S; Bruno, O; Brullo, C; Botta, Maurizio Not applicable
2008Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells.Spreafico, A; Schenone, S; Serchi, T; Orlandini, Maurizio ; Angelucci, A; Magrini, D; Bernardini, Giulia ; Collodel, Giulia; DI STEFANO, Anna; Tintori, C; Bologna, M; Manetti, Fabrizio ; Botta, Maurizio ; Santucci, Annalisa Not applicable
2012ATP-competitive inhibitors of mTOR: An updateSchenone, S; Brullo, C; Musumeci, F; Botta, Maurizio ; Botta, Maurizio Not applicable
2009C6-Unsubstituted Pyrazolo[3,4-d]pyrimidines Are Dual Src/Abl Inhibitors Effective against Imatinib Mesylate ResistantChronic Myeloid Leukemia Cell LinesSANTUCCI M., A; Corradi, V; Mancini, M; Manetti, Fabrizio ; Botta, Maurizio ; Schenone, S; Botta, Maurizio Not applicable
2007Construction and Validation of a RET TK Catalytic Domain by Homology ModelingTuccinardi, T; Manetti, Fabrizio ; Schenone, S; Martinelli, A; Botta, Maurizio Not applicable
2014CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction.Zamperini, Claudio; Dreassi, Elena ; Vignaroli, Giulia; Botta, Maurizio ; Dragoni, S; Schenone, S; Musumeci, Francesca; Valoti, Massimo; Antiochia, R; Botta, Maurizio Not applicable
2010Design and synthesis of Thiadiazoles and Thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitorsBotta, Maurizio ; Crespan, E; Falchi, F; Bernardo, V; Zanoli, S; Manetti, Fabrizio ; Schenone, S; Maga, G; Botta, Maurizio Not applicable
2009Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological dataDreassi, Elena ; Zizzari, ALESSANDRA TANIA; Falchi, Federico; Schenone, S; Santucci, Annalisa ; Maga, G; Botta, Maurizio Not applicable
2008Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agentsBotta, Maurizio ; Crespan, E; Botta, G; Falchi, F; Maga, G; Manetti, Fabrizio ; Corradi, V; Mancini, M; SANTUCCI M., A; Schenone, S; Botta, Maurizio Not applicable
2011Guanylated diamines, triamines, and polyamines: chemistry and biological properties.Castagnolo, Daniele; Schenone, S; Botta, Maurizio Not applicable
2007Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice.Manetti, Fabrizio ; Santucci, Annalisa ; Locatelli, Ga; Maga, G; Spreafico, A; Serchi, T; Orlandini, Maurizio ; Bernardini, Giulia ; Caradonna, Np; Spallarossa, A; Brullo, C; Schenone, S; Bruno, O; Ranise, A; Bondavalli, F; Hoffmann, O; Bologna, M; Angelucci, A; Botta, Maurizio Not applicable
2013Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents.Tintori, Cristina; Laurenzana, Ilaria; La Rocca, F; Falchi, Federico; Carraro, Fabio; Ruiz, A; Esté, Ja; Kissova, M; Crespan, E; Maga, G; Biava, M; Brullo, C; Schenone, S; Botta, Maurizio Not applicable
2009Indolyl-pyrrolone as a new scaffold for Pim1 inhibitorsOlla, S; Manetti, Fabrizio ; Crespan, E; Maga, G; Angelucci, A; Schenone, S; Bologna, M; Botta, Maurizio Not applicable
2007Inhibition of Bcr-Abl phosphorylation and induction of apoptosis by pyrazolo[3,4-d] pyrimidines in human leukemia cellsManetti, Fabrizio ; Pucci, Annalisa; Magnani, M; LOCATELLI G., A; Brullo, C; Naldini, Antonella; Schenone, S; Maga, G; Carraro, Fabio; Botta, Maurizio Not applicable
2007Last findings on dual inhibitors of Abl and Src tyrosine-kinasesSchenone, S; Manetti, Fabrizio ; Botta, Maurizio Not applicable
2010Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers.Kruewel, T; Schenone, S; Botta, Maurizio ; Maga, G; Rohrbeck, A; Botta, M; Borlak, J.Not applicable
2012New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization.Indovina, P; Giorgi, F; Rizzo, V; Khadang, B; Schenone, S; Di Marzo, D; Forte, Im; Tomei, V; Mattioli, E; D'Urso, V; Grilli, B; Botta, M; Giordano, Antonio; Pentimalli, F.Not applicable
2004New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylationSchenone, S; Bruno, O; Ranise, A; Bondavalli, F; Brullo, C; Fossa, P; Mosti, L; Menozzi, G; Carraro, Fabio; Naldini, Antonella; Bernini, C; Manetti, Fabrizio ; Botta, Maurizio Not applicable
2014Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma.Bernardini, Giulia ; Laschi, M; Serchi, T; Spreafico, Adriano; Botta, Maurizio ; Schenone, S; Arena, S; Geminiani, M; Scaloni, A; Collodel, G; Orlandini, M; Niccolai, Neri ; Santucci, Annalisa Not applicable