Browsing by Author Costi, Maria Paola

Showing results 1 to 13 of 13
Issue DateTitleAuthor(s)Third Mission
2019Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery PlatformMoraes, Carolina B.; Witt, Gesa; Kuzikov, Maria; Ellinger, Bernhard; Calogeropoulou, Theodora; Prousis, Kyriakos C.; Mangani, Stefano ; Di Pisa, Flavio; Landi, Giacomo; Iacono, Lucia Dello; Pozzi, Cecilia ; Freitas-Junior, Lucio H.; dos Santos Pascoalino, Bruno; Bertolacini, Claudia P.; Behrens, Birte; Keminer, Oliver; Leu, Jennifer; Wolf, Markus; Reinshagen, Jeanette; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Venturelli, Alberto; Wrigley, Stephen; Karunakaran, Deepa; Kebede, Bethlehem; Pöhner, Ina; Müller, Wolfgang; Panecka-Hofman, Joanna; Wade, Rebecca C.; Fenske, Martina; Clos, Joachim; Alunda, José María; Corral, María Jesús; Uliassi, Elisa; Bolognesi, Maria Laura; Linciano, Pasquale; Quotadamo, Antonio; Ferrari, Stefania; Santucci, Matteo; Borsari, Chiara; Costi, Maria Paola; Gul, SherazNot applicable
2017Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activityDI PISA, Flavio; Landi, Giacomo; DELLO IACONO, Lucia; Pozzi, Cecilia ; Borsari, Chiara; Ferrari, Stefania; Santucci, Matteo; Santarem, Nuno; Cordeiro Da Silva, Anabela; Moraes, Carolina B.; Alcantara, Laura M.; Fontana, Vanessa; Freitas Junior, Lucio H.; Gul, Sheraz; Kuzikov, Maria; Behrens, Birte; Pöhner, Ina; Wade, Rebecca C.; Costi, Maria Paola; Mangani, Stefano Not applicable
2017Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitorsPanecka-Hofman, Joanna; Pöhner, Ina; Spyrakis, Francesca; Zeppelin, Talia; Di Pisa, Flavio; Dello Iacono, Lucia; Bonucci, Alessio; Quotadamo, Antonio; Venturelli, Alberto; Mangani, Stefano ; Costi, Maria Paola; Wade, Rebecca C.Not applicable
2017Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamasesSantucci, Matteo; Spyrakis, Francesca; Cross, Simon; Quotadamo, Antonio; Farina, Davide; Tondi, Donatella; De Luca, Filomena; Docquier, Jean-Denis; Prieto, Ana Isabel; Ibacache, Claudia; Blázquez, Jesús; Venturelli, Alberto; Cruciani, Gabriele; Costi, Maria PaolaNot applicable
2019Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic InfectionsLinciano, Pasquale; Pozzi, Cecilia ; Iacono, Lucia Dello; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Santarem, Nuno; Baptista, Catarina; Franco, Caio; Moraes, Carolina B; Müller, Wolfgang; Wittig, Ulrike; Luciani, Rosaria; Sesenna, Antony; Quotadamo, Antonio; Ferrari, Stefania; Pöhner, Ina; Cordeiro-da-Silva, Anabela; Mangani, Stefano ; Costantino, Luca; Costi, Maria PaolaNot applicable
2019Evidence of destabilization of the human thymidylate synthase (hTS) dimeric structure induced by the interface mutation Q62RPozzi, Cecilia ; Lopresti, Ludovica ; Santucci, Matteo; Costi, Maria Paola; Mangani, Stefano Not applicable
2017Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug DiscoveryLinciano, Pasquale; Dawson, Alice; Pöhner, Ina; Costa, David M; Sá, Monica S; Cordeiro da silva, Anabela; Luciani, Rosaria; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Gribbon, Philip; Reinshagen, Jeanette; Wolf, Markus; Behrens, Birte; Hannaert, Veronique; Michels, Paul A. M; Nerini, Erika; Pozzi, Cecilia ; DI PISA, Flavio; Landi, Giacomo; Santarem, Nuno; Ferrari, Stefania; Saxena, Puneet; Lazzari, Sandra; Cannazza, Giuseppe; Freitas junior, Lucio H; Moraes, Carolina B; Pascoalino, Bruno S; Alcântara, Laura M; Bertolacini, Claudia P; Fontana, Vanessa; Wittig, Ulrike; Müller, Wolfgang; Wade, Rebecca C; Hunter, William N; Mangani, Stefano ; Costantino, Luca; Costi, Maria PaolaNot applicable
2020High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitorLandi, Giacomo; Linciano, Pasquale; Tassone, Giusy ; Costi, Maria Paola; Mangani, Stefano ; Pozzi, Cecilia Not applicable
2015Hotspots in an Obligate Homodimeric Anticancer Target. Structural and Functional Effects of Interfacial Mutations in Human Thymidylate SynthaseSalo Ahen, Outi M. H; Tochowicz, Anna; Pozzi, Cecilia ; Cardinale, Daniela; Ferrari, Stefania; Boum, Yap; Mangani, Stefano ; Stroud, Robert M; Saxena, Puneet; Myllykallio, Hannu; Costi, Maria Paola; Ponterini, Glauco; Wade, Rebecca C.Not applicable
2016Profiling of flavonol derivatives for the development of antitrypanosomatidic drugsBorsari, Chiara; Lucian, Rosaria; Pozzi, Cecilia ; Poehner, Ina; Henrich, Stefan; Trande, Matteo; Cordeiro Da silva, Anabela; Santarem, Nuno; Baptista, Catarina; Tait, Annalisa; DI PISA, Flavio; DELLO IACONO, Lucia; Landi, Giacomo; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Reinshagen, Jeanette; Witt, Gesa; Gribbon, Philip; Kohler, Manfred; Keminer, Oliver; Behrens, Birte; Costantino, Luca; Nevado, Paloma Tejera; Bifeld, Eugenia; Eick, Julia; Clos, Joachim; Torrado, Juan; Jiménez Antón, María D.; Corral, María J.; Alunda, José Ma; Pellati, Federica; Wade, Rebecca C.; Ferrari, Stefania; Mangani, Stefano ; Costi, Maria PaolaNot applicable
2019Structural and functional characterization of the human thymidylate synthase (hTS) interface variant R175C, new perspectives for the development of hTS inhibitorsPozzi, Cecilia ; Ferrari, Stefania; Luciani, Rosaria; Costi, Maria Paola; Mangani, Stefano Not applicable
2019Structural comparison of enterococcus faecalis and human thymidylate synthase complexes with the substrate dUMP and its analogue FdUMP provides hints about enzyme conformational variabilitiesPozzi, Cecilia ; Ferrari, Stefania; Luciani, Rosaria; Tassone, Giusy ; Costi, Maria Paola; Mangani, Stefano Not applicable
2019Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 InhibitorsLandi, Giacomo; Linciano, Pasquale; Borsari, Chiara; Bertolacini, Claudia P; Moraes, Carolina B; Cordeiro-da-Silva, Anabela; Gul, Sheraz; Witt, Gesa; Kuzikov, Maria; Costi, Maria Paola; Pozzi, Cecilia ; Mangani, Stefano Not applicable